DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20214603

Investigation of hesitancy to donate plasma among COVID-19 survivors in Goa: an online survey

Nitin Y. Dhupdale, Vedang Sawant, Bolivia Crocete Aloysia Fernandes, Jagadish Cacodcar, Steffi Barretto

Abstract


Background: The ongoing COVID-19 pandemic led to surge in mortality. In the absence of definitive treatment, convalescent plasma therapy was accepted as a modality to treat COVID-19 patients. There exists hesitancy with regards to COVID-19 convalescent plasma donation. The objective of this study is to find the deterrents to CCP donation.

Methods: An online survey was conducted by snowball technique. The study participants were COVID-19 survivors. They were asked to express their willingness to donate CCP. The reasons for not donating CCP were recorded. The data was analyzed using R-program. The adjusted and unadjusted Odds ratios were calculated to find the predictors of willingness to donate CCP.

Results: 110 study participants responded to the survey. 49.1% of the responders were willing to donate plasma. The top three deterrents of CCP donation were ill health (27.6%; 95% CI, 18.28%-39.27%), ineligibility (10.5%; 95% CI, 4.98%-20.21%), not recovered completely (6.58%; 95% CI, 2.45%-15.34%). The female gender, older age, being symptomatic, unaware of government incentives, tested by RAT, and unaware of CPT were associated with lower odds of donating CCP.

Conclusions: Ill health, ineligibility, and perceived incomplete recovery were the major deterrents of CCP donation. Being female, older age, being symptomatic, unaware of government incentives, tested by RAT, and unaware of CPT were associated with lower willingness to donate CCP. There is a need to develop interventions to target these factors to improve CCP donation whenever it is indicated.


Keywords


COVID-19, SARS-CoV-2, Convalescent plasma therapy, Deterrents, COVID-19 plasma donation

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References


Graham BS, Ambrosino DM. History of passive antibody administration for prevention and treatment of infectious diseases. Curr Opinion HIV AIDS. 2015; 10(3):129-34.

Luke TC, Kilbane EM, Jackson JL, Hoffman SL. Meta-Analysis: Convalescent Blood products for spanish influenza pneumonia: a future H5N1 treatment? Ann Internal Med. 2006;145(8):599-609.

FDA updates emergency use authorization for COVID-19 Convalescent plasma to reflect new data. Available at: https://www.fda.gov/news-events/fda-brief/fda-brief-fda-updates-emergency-use-authorization-covid-19-convalescent-plasma-reflect-new-data. Accessed on 20 September 2021.

Rajendran K, Krishnasamy N, Rangarajan J, Rathinam J, Natarajan M, Ramachandran A. Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. J Med Virol. 2020;92: 1475-83.

FDA Issues emergency use authorization for convalescent plasma as potential promising COVID–19 treatment, another achievement in administration’s fight against pandemic. Available at: https://www.fda. gov/news-events/press-announcements/fda-issues-emergency-use-authorization-convalescent-plasma-potential-promising-covid-19-treatment. Accessed on 20 September 2021.

FDA guidance on COVID-19. Available at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/investigational-covid-19-convalescent-plasma. Accessed on 20 September 2021.

Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 Critically Ill patients with COVID-19 With Convalescent Plasma. JAMA. 2020;323(16): 1582.

Karbiener M, Farcet MR, Ilk R, Schreiner J, Lenart J, Powers N, et al. Longitudinal analysis of SARS-CoV-2 antibodies in 8000 U.S. first-time convalescent plasma donations. Transfusion. 2021;61(4):1141-7.

O’Donnell MR, Grinsztejn B, Cummings MJ, Justman J, Lamb MR, Eckhardt CM, et al. A randomized, double-blind, controlled trial of convalescent plasma in adults with severe COVID-19. medRxiv. 2021; 2021:21253373.

Simonovich VA, Burgos Pratx LD, Scibona P, Beruto MV, Vallone MG, Vázquez C, et al. A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia. N Engl J Med. 2021;384(7):619-29.

COVID-19 Update ministry of health and family welfare. Available at: https://www.mohfw.gov.in/. Accessed on 20 September 2021.

Clinical guidance for management of adult COVID-19 patients. Available at: https://covid.aiims.edu/clinical-guidance-for-management-of-adult-covid-19-patients/. Accessed on 20 September 2021.

Health minister vishwajit rane appealing COVID warriors to come forward and donate their plasma. Available at: https://rdxgoa.com/health-minister-vishwajit-rane-appealing-covid-warriors-to-come-forward-and-donate-their-plasma/. Accessed on 20 September 2021.

Goa: GMC starts plasma donation campaign after donor numbers dip. Available at: https://timesofindia.indiatimes.com/city/goa/gmc-starts-plasma-donation-campaign-after-donor-nos-dip/articleshow/79888862.cms. Accessed on 20 September 2021.

Snowball Sampling: definition + examples. Available at: https://www.statology.org/snowball-sampling/. Accessed on 20 September 2021.

CRAN-Mirrors. Available at: https://cran.r-project.org/mirrors.html. Accessed on 20 September 2021.

nMaster 2.0 - Sample size software. Available at: https://www.cmc-biostatistics.ac.in/nmaster/. Accessed on 20 September 2021.

Molbio Diagnostics Pvt. Ltd. Available at: https://www.molbiodiagnostics.com/. Accessed on 20 September 2021.

IANS. Goa offers free treatment, complimentary check-ups for plasma donors [Internet]. The Bridge Chronicle. Available at: https://www.thebridge chronicle.com/news/nation/goa-offers-free-treatment-complimentary-check-ups-plasma-donors-55300. Accessed on 20 September 2021.

Free treatment, complimentary check-ups for plasma donors in Goa. Available at: https://latestnews. fresherslive.com/articles/free-treatment-complimentary-check-ups-for-plasma-donors-in-goa-148440. Accessed on 20 September 2021.

Masser BM, Ferguson E, Thorpe R, Lawrence C, Davison TE, Hoad V, et al. Motivators of and barriers to becoming a COVID-19 convalescent plasma donor: A survey study. Transfus Med. 2021;41:23-9.

Dhiman Y, Coshic P, Pandey HC, Khatiwada B, Singh J, Mehta V, et al. Deterrents in recruitment of COVID-19 convalescent plasma donors: Experience from a hospital-based blood centre in India. Transfus Med. 2021;41:35-8.

Mahapatra S, Pati S. Constraints, and challenges in convalescent plasma collection amidst the Covid 19 pandemic- strategies and recommendations to overcome these. Transfus Clinique et Biologique. 2021;28(2):175-9.