DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20201044

Collision of two epidemics: prevalence of diabetes in tuberculosis patients in urban Ludhiana

Vijayalakshmi Eruva, Clarence James Samuel, Shavinder Singh

Abstract


Background: Co-association between tuberculosis (TB) and diabetes has been observed for more than 2000 years. The burden of the both diabetes and tuberculosis is very high in India. Diabetes in TB patient decreases the success of anti-tubercular therapy and overall cure rates, which causes social and economic burden to country. The objective of the study was to find out the prevalence of diabetes mellitus in patients with tuberculosis under RNTCP treatment.

Methods: This cross-sectional study was conducted in DOTS centers under Civil Hospital TU of Ludhiana, Punjab. 300 TB cases, above 18 years of age were included and screened for diabetes. Patients were interviewed regarding demographic profile and family history of diabetes. Height, weight, blood pressure, BMI and waist hip ratio were recorded.

Results: The prevalence of diabetes in tuberculosis patients was found to be 21.3% (known diabetics- 6.3%, new diabetes cases- 15%). There was a statistically significant association of diabetes with older age and high BMI.

Conclusions: Specific guidelines for management of the dual disease may help in improving the overall success of treatment.


Keywords


Tuberculosis, Diabetes mellitus, Epidemics, Fasting blood sugar

Full Text:

PDF

References


Barach JH. Historical facts in Diabetes: Ann Med Hist. 1928;10:387-401.

Broxmeyer L. Diabetes Mellitus, Tuberculosis and mycobacteria: Two Millennia of Enigma. Med Hypothesis. 2005;65(3):433-39.

Jeon CY, Murray MB: Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLOS Med. 2008;5(7):1091-101.

Winterbauer R, Bedon G, Ball W. Recurrent Pneumonia: Predisposing illness &clinical pattern of 158 patients. Ann Intern Med. 1969;70:689.

Mboussa J, Monabeka H, Kombo M, Yokolo D, Mbio YA, Yala F: Course of tuberculosis in diabetics. Rev Pneumol Clin. 2003;59(1):39-44.

Dooley KE, Tang T, Glob JE, Dorman SE, Cronin W: Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis. Am J Trop Med Hyg. 2009;80(4):634-9.

Harries AD, Murray MB, Jeon CY, Ottmani SE, Lonnroth K, Barreto ML et al. Defining the research agenda to reduce the joint burden of disease from diabetes mellitus and tuberculosis. Trop Med Int Health. 2010;15:659-63.

Sen T, Joshi SR, Udwadia ZF. Tuberculosis and Diabetes Mellitus: Merging epidemics. J Assoc Physicians India. 2009;57:399-404.

TB India: Annual Status Report, RNTCP. CTD, MOH and FW, New Delhi, 2015.

The IDF Diabetes Atlas: A Summary of Figures and Key Findings. 7th ed. International Diabetes Federation.

Collaborative framework for care and control of tuberculosis and diabetes: Report by WHO and IUATLD.

Viswanathan V, Kumpatla S, Aravindalochanan V, Rajan R, Chinnasamy C, Srinivasa R et al. Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India. PLOS one. 2012;7(7):41367.

Balakrishnan S, Vijayan S, Nair S, Subramoniapillai J, Mrithyunjayan S, Wilson N et al. High diabetes prevalence among tuberculosis cases in Kerala, India. PLOS one 2012;7:46502.

Raghuraman S, Vasudevan KP, Govindarajan S, Chinnakali P, Panigrahi KC. Prevalence of diabetes mellitus among tuberculosis patients in urban Puduchery. North Am J Med Sci. 2014;6:30-4.

Bhupendra KR, Arun KS, Narmada PP, Roopesh J, Pranav R, Singh DP et al. Prevalence of Diabetes Mellitus in Tuberculosis Patient: A Tertiary Care Centre Study from Central India. J Evol Med Den Sci. 2014;29:8155-61.

Qing Z, Heping X, Isamu S. Tuberculosis Complicated by Diabetes Mellitus at Shanghai Pulmonary Hospital, China. Jpn J Infect Dis. 2009;62:390-91.

Singla R, Khan N, Sharif AN, Sayegh AMO, Shaikh MA, Osman MM. Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients. Int J Tuberclung Dis. 2006;10(1):74-7.

Corona JME, Hervert CLP, Garcia GL, Reyes FL, Sanchez DG, Valle BDM, et al. Association of diabetes and tuberculosis: impact on treatment and post-treatment outcomes. Thorax. 2013;68:214-20.

Singh A, Shenoy S, Sandhu JS. Prevalence of Hypertension and its Risk Factors among Urban Sikh Population of Amritsar. Int J Sci Res. 2014;3(3):827-32.

Manoj DK, Rajani M, Achuthan V, Smitha N. Prevalence of diabetes mellitus in tuberculosis patients: a hospital-based study. Int J Res Med Sci. 2015;3(10):2810-14.

WHO. Diet, nutrition and the prevention of chronic diseases. 2015.

Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: WHO, 2006;3.

World Health Organization. Treatment of tuberculosis guidelines, 4th edition; 2013.

Anjana RM, Pradeepa R, Deepa M, Datta M, Sudha V, Unnikrishnan A et al. ICMR-INDIA Collaborative Study Group. Prevalence of diabetes and prediabetes (impaired fasting glucose and impaired glucose tolerance) in urban and rural India: phase I results of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study. Diabetologia. 2011;54(12):3022-27.